The Arizona Cardinals will start Emari Demercado at running back for their game on Sunday, October 6, 2025, against the Tennessee Titans. This change comes after rookie Trey Benson was placed on injured reserve with a knee injury that will keep him out for at least four weeks, and James Conner is already out for the season due to a foot injury. Demercado, who has shown versatility and pass-catching ability, will likely handle more of the inside carries, while Michael Carter will share the workload with him, especially in passing plays. Bam Knight is expected to be the third running back in the rotation. Head coach Jonathan Gannon expressed confidence in Demercado, Carter, and Knight to step up and carry the backfield duties for now.