NyQuil use during pregnancy depends on the specific product and its ingredients. Liquid NyQuil products containing alcohol should be avoided throughout pregnancy. NyQuil Severe Cold & Flu, which contains phenylephrine, should not be used in the first trimester and only with a doctor's approval later in pregnancy because of potential risks. Other NyQuil products with acetaminophen, doxylamine, and dextromethorphan are generally considered safe but should still be taken only after consulting with a healthcare provider. Overall, it's best to avoid combination medications if possible and to seek safer alternatives for cold and flu symptom relief during pregnancy.