Vyvanse typically starts to work within 1 to 2 hours after taking it, with many people feeling effects as soon as 30 to 60 minutes. The peak effects usually occur around 3 to 4 hours post-dose, and the medication's effects can last up to 12 to 14 hours. How quickly Vyvanse works can depend on factors such as metabolism, dosage, and whether it's taken with food. For example, taking Vyvanse on an empty stomach may lead to quicker onset compared to taking it with a heavy meal. The drug's effects include improved focus, attention, and reduced impulsive behavior in individuals with ADHD, and it may take a few weeks to achieve maximum benefit.